abstract：:Endothelin-1 (ET-1) is a powerful vasoconstrictor peptide and regulator of blood flow that plays an important role in blood pressure (BP) elevation in some models of experimental hypertension such as DOCA-salt rat, DOCA-salt-treated spontaneously hypertensive rats (SHR), stroke-prone SHR, Dahl salt-sensitive rats, ang...

journal_title：American journal of hypertension

authors： Schiffrin EL

更新日期：2001-06-01 00:00:00

abstract：:A wide pulse pressure (PP) may constitute an independent predictor of cardiovascular morbidity and mortality. We assessed the reference values of brachial clinic PP, according to age and gender in a nonselected population (61,724 subjects) who were undergoing a routine systematic health examination. According to mean ...

journal_title：American journal of hypertension

authors： Asmar R,Vol S,Brisac AM,Tichet J,Topouchian J

更新日期：2001-05-01 00:00:00

abstract：:Antihypertensive drugs are often initiated and adjusted over a period of weeks to months. It is not clear whether the time and inconvenience of this approach is necessary. We studied whether or not drug adjustment over several days in the context of a physician-nurse team could produce a durable blood pressure benefit...

journal_title：American journal of hypertension

authors： Canzanello VJ,Jensen PL,Hunder I

更新日期：2001-04-01 00:00:00

abstract：:The renin-angiotensin-aldosterone system plays a major role in the pathogenesis of hypertension by enhancing the production or the activity of angiotensin II (ANG II). We evaluated the effects of hormone replacement therapy (HRT) on the renin-angiotensin-aldosterone system and on bradykinin in postmenopausal women (PM...

journal_title：American journal of hypertension

authors： Umeda M,Ichikawa S,Kanda T,Sumino H,Kobayashi I

更新日期：2001-03-01 00:00:00

abstract：:The changes induced by transient hypertension on cardiac structure and function are unclear. Pregnancy-induced hypertension offers a natural and spontaneous model of this condition. To assess the potential of echocardiographic Doppler to unmask left ventricular function impairment, we studied 28 women aged 26.4 +/- 7....

journal_title：American journal of hypertension

authors： Vázquez Blanco M,Roisinblit J,Grosso O,Rodriguez G,Robert S,Berensztein CS,Vega HR,Lerman J

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Left ventricular (LV) hypertrophy and impaired diastolic function may occur early in systemic hypertension, but longitudinal studies are missing. METHODS:We performed an echocardiographic follow-up study in young initially normotensive male offspring of hypertensive (OHyp) (n = 25) and normotensive (ONorm) ...

journal_title：American journal of hypertension

authors： Aeschbacher BC,Hutter D,Fuhrer J,Weidmann P,Delacrétaz E,Allemann Y

更新日期：2001-02-01 00:00:00

abstract：:Left ventricular hypertrophy in patients with hypertension is an important condition. It is associated with significant mortality and carries increased risk for developing nonfatal cardiovascular complications, including coronary heart disease. The pathogenesis of left ventricular hypertrophy is linked to activation o...

journal_title：American journal of hypertension

authors： Dahlöf B

更新日期：2001-02-01 00:00:00

abstract：:Stroke-prone spontaneously hypertensive rats (SHRSP), subjected to high NaCl, show severe hypertension, organ damage, and early death. Preventive treatment with angiotensin II type 1 (AT1) receptor antagonists is known to be effective. Previously, we found that angiotensin converting enzyme (ACE) inhibition could redu...

journal_title：American journal of hypertension

authors： Blezer EL,Nicolay K,Koomans HA,Joles JA

更新日期：2001-01-01 00:00:00

abstract：:Components of the kallikrein kinin system have been associated with the pathophysiology of hypertension in animal and human studies. In this study, we examined the distribution of four different polymorphisms of the kinin B1 and B2 receptor genes in a population of 120 normotensive and 77 hypertensive African-American...

journal_title：American journal of hypertension

authors： Gainer JV,Brown NJ,Bachvarova M,Bastien L,Maltais I,Marceau F,Bachvarov DR

更新日期：2000-12-01 00:00:00

abstract：:Changes in the lipid composition of the membrane affect its fluidity and function. These variables are altered in various forms of hypertension. Our hypothesis was that the rapid increase in blood pressure (BP) caused by inhibition of nitric oxide production would lead to alterations in membrane fluidity similar to th...

journal_title：American journal of hypertension

authors： McLauren Dorrance A,Graham D,Dominiczak A,Fraser R

更新日期：2000-11-01 00:00:00

abstract：:The aim of this study was to assess the contribution of physical activity levels to blood pressure (BP) variability, and to assess the effect age, gender, body mass index, and use of antihypertensive medications on this relationship. We simultaneously monitored 24-h ambulatory BP by automated recorder and activity by ...

journal_title：American journal of hypertension

authors： Leary AC,Donnan PT,MacDonald TM,Murphy MB

更新日期：2000-10-01 00:00:00

abstract：:Stroke (brain attack) is currently the third leading cause of death in Western societies. Recent advances in molecular genetics have finally demonstrated what has long been suggested by the clinical observation, that is, stroke is not only the complication of major pathologic conditions such as atherosclerosis, hypert...

journal_title：American journal of hypertension

authors： Rubattu S,Giliberti R,Volpe M

更新日期：2000-10-01 00:00:00

abstract：:Inhibition of calcineurin-mediated signaling in T lymphocytes is a major mechanism of cyclosporine A (CsA)-induced immunosuppression, and previous rat studies have suggested that inhibition of calcineurin-mediated signaling in central neuronal pools involved in blood pressure regulation plays an important role in caus...

journal_title：American journal of hypertension

authors： Zhang W,Victor RG

更新日期：2000-09-01 00:00:00

abstract：:Leptin, the gene product of the ob gene, is influenced by gender and insulin sensitivity. Because in human hypertension there are important endocrine-hemodynamic gender-dependent differences, we compared plasma leptin in 39 essential hypertensives (EH) and in 27 normotensive healthy subjects (HS) matched for gender, a...

journal_title：American journal of hypertension

authors： Mallamaci F,Cuzzola F,Tripepi G,Cutrupi S,Parlongo S,Tripepi R,Zoccali C

更新日期：2000-08-01 00:00:00

abstract：:Essential hypertension is often accompanied by abnormalities of the coagulation/fibrinolytic system, predisposing to a procoagulant state. The aim of the present study was to compare the effects of atenolol (beta1-blocker agent) and irbesartan (angiotensin II type 1 receptor antagonist) on plasma levels of hemostatic/...

journal_title：American journal of hypertension

authors： Makris TK,Stavroulakis GA,Krespi PG,Hatzizacharias AN,Triposkiadis FK,Tsoukala CG,Votteas VV,Kyriakidis MK

更新日期：2000-07-01 00:00:00

abstract：:Essential hypertension conveys an increased risk of cardiovascular morbidity and mortality. The common finding of an autonomic imbalance in these patients contributes not only to the etiology of hypertension itself, but also to the cardiac risk and resulting adverse sequelae. A high sympathetic tone in particular is r...

journal_title：American journal of hypertension

authors： Brook RD,Julius S

更新日期：2000-06-01 00:00:00

abstract：:To assess whether aerobic exercise training is an effective and an alternative method to control blood pressure (BP) in hypertension, 32 uncomplicated, never treated patients suffering from mild-to-moderate essential arterial hypertension (EAH) were included in an aerobic exercise training program using a regular stan...

journal_title：American journal of hypertension

authors： Nami R,Mondillo S,Agricola E,Lenti S,Ferro G,Nami N,Tarantino M,Glauco G,Spanò E,Gennari C

更新日期：2000-06-01 00:00:00

abstract：:The induction of learned helpless (LH) behavior in rats is a widely used model of unipolar depression. Recent studies have linked depression with hypertension and insulin resistance as observed in obesity, but the propensity of these disorders to manifest depression has not been reported. In this study, the LH behavio...

journal_title：American journal of hypertension

authors： Edwards E,King JA,Fray J

更新日期：2000-06-01 00:00:00

abstract：:Our objective was to evaluate pretreatment predictors of longevity, particularly blood pressure, in a large cohort of hypertensive men. During 1974 to 1976, 10,367 male hypertensive veterans (47% black) were identified at screening and subsequently characterized in 32 special Veterans Administration (VA) hypertension ...

journal_title：American journal of hypertension

authors： Perry HM Jr,Miller JP,Baty JD,Carmody SE,Sambhi MP

更新日期：2000-06-01 00:00:00

abstract：:To examine the influence of angiotensin-converting enzyme (ACE) on pressor, renal vascular, and adrenal responses during angiotensin I (Ang I) infusion, we studied 10 normotensive, healthy men. Each was in balance with a 10-mEq sodium, 100-mEq potassium intake and was studied before and during ACE inhibition with enal...

journal_title：American journal of hypertension

authors： Hollenberg NK,Fisher ND,Price DA,Williams GH

更新日期：2000-05-01 00:00:00

abstract：:We have previously reported that weight gain induced by high-fat diet (HFD) leads to an increase in mean arterial pressure (MAP, +14%) and heart rate (HR, +31%) in the adult rabbit. In the present study, we tested the hypothesis that an increased activity of the sympathetic nervous system may contribute to the develop...

journal_title：American journal of hypertension

authors： Antic V,Kiener-Belforti F,Tempini A,Van Vliet BN,Montani JP

更新日期：2000-05-01 00:00:00

abstract：:Despite advances in the availability and quality of antihypertensive medications and the institution of national programs to educate people about the seriousness of hypertension, much remains to be done. The percentages of people who are aware of their disease, are being treated for it, and are achieving adequate cont...

journal_title：American journal of hypertension

authors： Julius S

更新日期：2000-05-01 00:00:00

abstract：:Our objective was to describe the relationship of arterial stiffness and hypertension in a large, population-based sample of men and women. Hypertension-related increases in arterial stiffness may reflect the distending pressure and/or structural alterations in the artery. Included were 10,712 participants, ages 45 to...

journal_title：American journal of hypertension

authors： Arnett DK,Boland LL,Evans GW,Riley W,Barnes R,Tyroler HA,Heiss G

更新日期：2000-04-01 00:00:00

abstract：:Insulin acutely inhibits contraction of primary cultured vascular smooth muscle (VSM) cells from canine femoral artery by inhibiting contractile agonist-induced Ca2+ influx. Insulin also inhibits contraction at step(s) distal to intracellular Ca2+ concentration (Ca2+i) by stimulating cyclic guanosine monophosphate (GM...

journal_title：American journal of hypertension

authors： Kahn AM,Allen JC,Seidel CL,Song T

更新日期：2000-04-01 00:00:00

abstract：:Angiotensin receptors became relatively easy to study when radioactive derivatives of the peptide were synthesized for radioimmunoassays. Binding assays in vitro led to the discovery of receptors in many tissues different from those involved in the classic actions of angiotensin. The physiologic significance of recept...

journal_title：American journal of hypertension

authors： Goodfriend TL

更新日期：2000-04-01 00:00:00

abstract：:We studied how closely changes in electronically monitored physical activity are reflected in changes in blood pressure and heart rate in a group of untreated hypertensive subjects. Thirty-nine hypertensive patients (office blood pressure > 140/ 90 mm Hg) of mean age 57 +/- 10 years (mean +/-SD) wore an ambulatory blo...

journal_title：American journal of hypertension

authors： Mansoor GA,White WB,McCabe EJ,Giacco S

更新日期：2000-03-01 00:00:00

abstract：:The polymorphism of the angiotensin-converting enzyme gene is considered to be associated with increased risk for stroke, but there is a diversity in the results obtained. The genetic involvement of the renin-angiotensin system in stroke also remains unclear. To predict the genetic risk of lacunar infarction, we condu...

journal_title：American journal of hypertension

authors： Takami S,Imai Y,Katsuya T,Ohkubo T,Tsuji I,Nagai K,Satoh H,Hisamichi S,Higaki J,Ogihara T

更新日期：2000-02-01 00:00:00

abstract：:Angiotensin II (Ang II) and transforming growth factor-beta (TGF-beta) modulate cell growth and metabolism. Our objective was to evaluate the effect of Ang II on the characteristics and expression of TGF-beta receptors on vascular smooth muscle cells (VSMC) from Wistar-Kyoto rats. The addition of TGF-beta1 elicited a ...

journal_title：American journal of hypertension

authors： Fukuda N,Hu WY,Kubo A,Kishioka H,Satoh C,Soma M,Izumi Y,Kanmatsuse K

更新日期：2000-02-01 00:00:00

abstract：:We sought to determine whether reductions in blood pressure in hypertensives after acute exercise persist for more than the 2 to 3 h found in controlled laboratory settings. Subjects (n = 11) were obese (32 +/- 4% body fat), sedentary (VO2max 27 +/- 4 mL/kg/min) 60 +/- 6-year-old men with stage 1 or 2 essential hypert...

journal_title：American journal of hypertension

authors： Taylor-Tolbert NS,Dengel DR,Brown MD,McCole SD,Pratley RE,Ferrell RE,Hagberg JM

更新日期：2000-01-01 00:00:00

abstract：:High levels of plasma homocyst(e)ine (H[e]) are associated with increased vascular risk. Treatment is being contemplated, but the level at which patients should be treated is not known. We compared the response of carotid plaque to vitamin therapy in patients with H(e) above and below 14 micromol/L, a level commonly r...

journal_title：American journal of hypertension

authors： Hackam DG,Peterson JC,Spence JD

更新日期：2000-01-01 00:00:00

abstract：:Left ventricular hypertrophy (LVH) has been identified as one of the strongest blood pressure-independent risk factors for sudden death, acute myocardial infarction, congestive heart failure, and other cardiovascular morbidity and mortality. Hypertensive patients with LVH have a significantly greater prevalence of pre...

journal_title：American journal of hypertension

authors： Messerli FH

更新日期：1999-12-01 00:00:00

abstract：:The purpose of this double-blind, forced titration study was to compare the antihypertensive effect duration of candesartan cilexetil, which has a longlasting binding to the human AT1-receptor, to that of losartan on ambulatory BP (ABP) not only during the 24-h dosing interval but also during the day of a missed dose ...

journal_title：American journal of hypertension

authors： Lacourcière Y,Asmar R

更新日期：1999-12-01 00:00:00

abstract：:The antidiabetic drug metformin lowers blood pressure (BP) more in spontaneously hypertensive rats (SHR) compared with Wistar-Kyoto rats (WKY), and the hypotensive effect is enhanced by high dietary salt. To determine whether enhanced hypotension is secondary to greater decreases in sympathetic nerve activity (SNA), w...

journal_title：American journal of hypertension

authors： Muntzel MS,Nyeduala B,Barrett S

更新日期：1999-12-01 00:00:00

abstract：:Cold- and insulin-mediated release of angiotensin II (AII) and endothelin-1 (ET-1), as well as vascular reactivity to exogenous ET-1 and to insulin, were compared in hypertensive and normotensive subjects. Peripheral vascular release of AII and of ET-1 was investigated in 10 hypertensive (H; 29.2+/-5.8 years) and 12 n...

journal_title：American journal of hypertension

authors： Gasic S,Ratheiser K,Wagner O,Nowotny P,Vierhapper H,Waldhäusl W

更新日期：1999-11-01 00:00:00

abstract：:The purpose of this study was to determine whether cold-stress stimulation to the soles of paws produces continuous hypertension in rats. Wistar-Kyoto rats were kept in cages with a 0 degrees C floor and 23 degrees C room temperature (cold-stressed group, n = 10) or in cages with 23 degrees C floor and 23 degrees C ro...

journal_title：American journal of hypertension

authors： Kanayama N,Khatun S,Belayet H,She L,Terao T

更新日期：1999-11-01 00:00:00

abstract：:In recent years, several international bodies of experts have established extensive guidelines for the prevention and treatment of coronary heart disease (CHD) that clearly define the importance of altering patients' lifestyles and administering therapeutic agents that positively affect disease progression. However, s...

journal_title：American journal of hypertension

authors： Erhardt LR

更新日期：1999-10-01 00:00:00

abstract：:Barriers to high blood pressure (HBP) care and control have been reported in the literature for > 30 years. Few reports on barriers, however, have focused on the young black man with HBP, the age/sex/race group with the highest rates of early severe and complicated HBP and the lowest rates of awareness, treatment, and...

journal_title：American journal of hypertension

authors： Hill MN,Bone LR,Kim MT,Miller DJ,Dennison CR,Levine DM

更新日期：1999-10-01 00:00:00

abstract：:The benzothiazepine calcium channel antagonist diltiazem is a short-acting drug. To achieve effective 24-h blood pressure control with once-daily dosing, it relies on various extended drug-delivery systems that have grown in importance as a result of the recent reports relating the use of short-acting calcium channel ...

journal_title：American journal of hypertension

authors： Smith DH,Neutel JM,Weber MA

更新日期：1999-10-01 00:00:00

abstract：:The aim of the present study was to assess the efficacy and tolerability of a calcium antagonist/beta-blocker fixed combination tablet used as first-line antihypertesnive therapy in comparison with an angiotensin converting enzyme inhibitor and placebo. Patients with uncomplicated essential hypertension (diastolic blo...

journal_title：American journal of hypertension

authors： Waeber B,Detry JM,Dahlöf B,Puig JG,Gundersen T,Hosie J,Januszewicz W,Lindström CJ,Magometschnigg D,Safar M,Tanser P,Toutouzas P

更新日期：1999-09-01 00:00:00

abstract：:Antihypertensive monotherapy, although commonly used, does not address the multifactorial nature of hypertension as a disease with many pathways. Using more than one drug makes more therapeutic sense because combination agents cover more than one pathway, yet the use of drugs in tandem is typically relegated to more p...

journal_title：American journal of hypertension

authors： Neutel JM

更新日期：1999-08-01 00:00:00